Federico Mazzola's area of research focuses on the electronic structure and properties of quantum materials ranging from semiconductors, semimetals, topological insulators to superconductors, with particular interest in the many-body interactions that underpin their physical properties and how these can be tuned using quantum confinement and modifying their crystalline symmetry.

His work is motivated by the synthesis and study of novel systems, which could provide a suitable platform for integration with existing semiconductor-based technology.